Despite its limitations a 24 h urine collection is the best available tool to assess the contribution of dietary oxalate to urinary oxalate excretion. Oxalate is the anion of a strong dicarboxylic acid c 2 o 4 h 2 that arises in the body from a combination of dietary sources and endogenous synthesis from precursors such as ascorbate and various amino acids approximately 75 of all kidney stones are composed primarily of calcium oxalate with hyperoxaluria considered to be a primary risk factor for this type of stones. Dietary oxalate induces urinary nanocrystals in humans.
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