Dietary Oxalate To Urinary Oxalate Excretion
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Genetic and dietary influences on urinary oxalate excretion.
Dietary oxalate to urinary oxalate excretion. In normal individuals approximately half of urinary oxalate is derived from the diet and half from endogenous synthesis. Some research shows that increased oxalate intake may be linked to greater excretion of oxalate through the urine which may contribute to the development of kidney stones however increasing. Dietary oxalate and urinary oxalate excretion. P less than 0 01.
Comparisons of mean oxalate excretion on diets that differed in only one dietary component. On a hospital diet containing 1000 mg calcium per day urinary oxalate excretion fell significantly from 0 48 0 23 mmol d to 0 32 0 12. As the urinary calcium excretion in and out of hospital was similar it seems unlikely that low calcium intake at home was responsible for the hyperoxaluria. With oxalate containing diets the mean contribution of dietary oxalate to urinary oxalate excretion ranged from 24 4 15 5 on the 10 mg 2500 kcal day diet to 41 5 9 1 on the 250 mg 2500 kcal day diet much higher than previously estimated.
Urinary oxalate excretion increased as dietary oxalate intake increased. With oxalate containing diets the mean contribution of dietary oxalate to urinary oxalate excretion ranged from 24 4 15 5 on the 10 mg 2500 kcal day diet to 41 5 9 1 on the 250 mg 2500 kcal day diet much higher than previously estimated. Dietary oxalate and urinary oxalate excretion fig. With oxalate containing diets the mean contribution of dietary oxalate to urinary oxalate excretion ranged from 24 4 15 5 on the 10 mg 2500 kcal day diet to 41 5 9 1 on the 250 mg 2500 kcal day diet much higher than previously estimated.
Dietary oxalate is plant derived and may be a component of vegetables nuts fruits and grains. Effect of the oxalate content of the diet on urinary oxalate from 1002 mg 2500 kcal to 391 mg 2500 kcal. Holmes rp 1 assimos dg goodman ho. Hyperoxaluria defined as excessive urinary excretion of oxalate is associated with kidney stone formation and even oxalate nephropathy.
1 department of urology bowman gray school of medicine winston salem nc 27157 usa. 272 holmes et al. Urinary oxalate excretion increased as dietary oxalate intake increased. The deposition of calcium oxalate in the kidney can lead to progressive damage over time with the eventual development of chronic kidney disease ckd.
Rholmes bgsm edu several genes contribute to the development of calcium oxalate nephrolithiasis as it is a polygenic disease. Despite its limitations a 24 h urine collection is the best available tool to assess the contribution of dietary oxalate to urinary oxalate excretion.
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